Science % Research

The First Clinical Study Shows a Key NAD+ Intermediate NMN Safe for Human Use

A research team at Keio University has shown for the first time that nicotinamide mononucleotide (NMN), a promising compound for anti-aging intervention, can be safely administered to healthy humans. The...

Impairment of an Endothelial NAD +-H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in human health....

Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3‐dependent mechanism in male mice

Nicotinamide adenine dinucleotide (NAD+) is a central signaling molecule and enzyme cofactor that is involved in a variety of fundamental biological processes. NAD+ levels decline with age, neurodegenerative conditions, acute brain...

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